E.4b Neurotransmitters

depression

  • caused by deficiency of norepinephrine (NE) and/or serotonin (ST)
  • psychoactive drugs can increase the levels of NE/ST at synapses
  • increase in secretion of NE/ST from pre-synaptic neurons
  • suppression of NE/ST deactivating enzymes at post-synaptic neurons
  • inhibition of NE/ST uptake by pre-synaptic neurons
  • elevate mood in normal people
  • alleviate depression in the chronically depressed
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