depression
- caused by deficiency of norepinephrine (NE) and/or serotonin (ST)
- psychoactive drugs can increase the levels of NE/ST at synapses
- increase in secretion of NE/ST from pre-synaptic neurons
- suppression of NE/ST deactivating enzymes at post-synaptic neurons
- inhibition of NE/ST uptake by pre-synaptic neurons
- elevate mood in normal people
- alleviate depression in the chronically depressed
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